Professor Satya Parida is leading Vaccine Differentiation group in the livestock viral disease programme, world reference laboratory, the Pirbright Institute, UK, which carries out applied research that will help to control foot-and-mouth disease (FMD) and Peste des Petits ruminants (PPR). He is an adjunct professor to Murdoch University Australia and an investigator at the Jenner Institute, Oxford University. Recently he has joined at NIAB, Hyderabad as a visiting faculty in the infectious disease programme.

FMD and PPR Vaccines and diagnostics, Viral vectored based vaccine development using reverse genetics techniques, Immunological evaluations of conventional and new generation FMD and PPR vaccines.

The focus within the group is the development and validation of marker vaccines and associated diagnostics for FMD and PPR. We have three lines of investigation: (1) improving our understanding of what aspects of the immune response are important in protection of vaccinated animals against acute and persistent infection; (2) developing alternative means of detecting infection in vaccinated animals; and (3) developing and evaluating improved marker vaccines (DIVA vaccines) for FMD and PPR.

• Pope RA, Parida S, Bailey D, Brownlie J, Barrett T, Ashley C. Banyard. (2013) Early Events following Experimental Infection with Peste-Des-Petits Ruminants Virus Suggest Immune Cell Targeting. PLoS ONE 8(2): e55830. doi:10.1371/journal.pone.0055830

• Muniraju MB, El Harrak M, Bao J, Babu Aravindh,Banyard Ashley, Batten Carrie and Satya Parida (2013). Complete genome sequence of peste des petits ruminants virus recovered from an Alpine goat during a 2008 Moroccan outbreak. Genome Announc. 2013;1(3):00096-13. doi:10.1128/genomeA.00096-13.

• Oh Y, Fleming L, Statham B, Hamblin P, Barnett P, et al. (2012) Interferon-γ Induced by In Vitro Re-Stimulation of CD4+ T-Cells Correlates with In Vivo FMD Vaccine Induced Protection of Cattle against Disease and Persistent Infection. PLoS ONE 7(9): e44365. doi:10.1371/journal.pone.0044365

• Jingyue Bao, Qinghua Wang, Satya Parida, Chunju Liu, Ling Zhang, Wenji Zhao and Zhiliang Wang. 2012, Complete Genome Sequence of a Peste des Petits Ruminants Virus Recovered from Wild Bharal in Tibet, China. doi: 10.1128/JVI.01503-12 J. Virol. October 2012 vol. 86 no. 19 10885-10886

• El Harrak Mehdi, Touil Nadia, Loutfi Chafiqua, Hammouchi Mustapha, Parida Satya, Sebbar Gizlane, Chaffai Nadia, Harif Bachir, Messoudi Nezha, Batten Carrie, and Oura Chris.A.L(2012) A reliable and reproducible experimental challenge model for Peste-des-petits ruminants. J. Clin. Microbiol. doi:10.1128/JCM.01785-12.

• Buczkowski H, Parida S, Bailey D, Barrett T, Banyard ACA novel approach to generating morbillivirus vaccines: Negatively marking the rinderpest vaccine. Vaccine. 2012 2; 30(11):1927-35.

• Madhanmohan M, Nagendrakumar SB, Manikumar K, Yuvaraj S, Parida S, Srinivasan VA. (2012). Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid serotyping of foot-and-mouth disease virus. J Virol Methods. 2012 Aug 30. [Epub ahead of print

• Ko YJ, Lee HS, Park JH, Lee KN, Kim SM, Cho IS, Joo HD, Paik SG, Paton DJ, Parida S. Field application of a recombinant protein-based ELISA during the 2010 outbreak of foot-and-mouth disease type A in South Korea. J Virol Methods. 2012 Jan;179(1):265-8. Epub 2011 Oct 5

• Fowler V, Robinson L, Bankowski B, Cox S, Parida S, Lawlor C, Gibson D, O'Brien F, Ellefsen B, Hannaman D, Takamatsu HH, Barnett PV.A DNA vaccination regime including protein boost and electroporation protects cattle against foot-and-mouth disease. Antiviral Research 94 (2012), pp. 25-34 DOI information: 10.1016/j.antiviral.2012.02.002

• Baron MD, Parida S, Oura CA.Paste des petits ruminants: a suitable candidate for eradication? Vet Rec. 2011 Jul 2;169(1):16-21.

• Nagendrakumar SB, Srinivasan VA, Madhanmohan M, Yuvaraj S, Parida S, Di Nardo A, Horsington J, Paton DJ. Evaluation of cross-protection between O(1) Manisa and O(1) Campos in cattle vaccinated with foot-and-mouth disease virus vaccine incorporating different payloads of inactivated O(1) Manisa antigen. Vaccine. 2011 Feb 24;29(10):1906-12.

• Usman Waheed, Satya Parida, Qaiser M. Khan, Manzoor Hussain, Katja Ebert, Jemma Wadsworth, Scott M. Reid, Geoffrey H. Hutchings, Mana Mahapatra, Donald P. King, David J. Paton and Nick J. Knowles. (2011). Molecular Characterisation of Foot-and-Mouth Disease Viruses from Pakistan, 2005-2008. Trans and Emerg Dis, 58:166-172.

• Banyard AC, Parida S, Batten C, Oura C, Kwiatek O, Libeau G.Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. J Gen Virol. 2010 Dec; 91(Pt 12):2885-2897. Epub 2010 Sep 15

• Sen A, Saravanan P, Balamurugan V, Rajak KK, Sudhakar SB, Bhanuprakash V, Parida S, Singh RK. Vaccines against peste-des-petits-ruminants virus. Expert Rev Vaccines. 2010 Jul;9(7):785-96. Review.

• Uttenthal A, Parida S, Rasmussen TB, Paton DJ, Haas B, Dundon WG.(2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Rev Vaccines. 2010 Jan;9(1):73-87.

• Sarah J. Coxa,B. Veronica Carrb, Satya Parida, Pip A. Hamblina, Helen Prenticeb,Bryan Charlestonb, David J. Patona, Paul V. Barnett (2010) Longevity of protection in cattle following immunisation with emergency FMD A22 serotype vaccine from the UK strategic reserve. Vaccine, 8;28(11):2318-22.

• Paton DJ, Ferris NP, Hutchings GH, Li Y, Swabey K, Keel P, Hamblin P, King DP, Reid SM, Ebert K, Parida S, Savva S, Georgiou K, Kakoyiannis C.(2009) Investigations into the cause of foot-and-mouth disease virus seropositive small ruminants in Cyprus during 2007. Transbound Emerg Dis. 2009 Oct;56(8):321-328.

• Satya Parida (2009) Vaccination against foot-and-mouth disease virus: strategies and effectiveness. “Expert Review Vaccine”, 8 (3), 347-365.

• Rémond M, Bruno Da Costa, Sabine Riffault b, Satya Parida, Emmanuel Brearda, Franc¸ oise Lebretona, Stephan Zientaraa, Bernard Delmas (2009). Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site. Vaccine. 27:93-98.

• D. Schley, D.J. Paton, S.J. Cox, S. Parida & S. Gubbins. The effect of vaccination on undetected persistence of foot-and-mouth disease virus in cattle herds and sheep flocks. Epidemiology and Infection. Epidemiol. Infect. (2009), 137, 1494–1504

• S Parida, L Fleming, Y Oh, M Mahapatra, P Hamblin, J Gloster and D J Paton. (2008) Emergency vaccination of sheep against foot-and-mouth disease: significance and detection of subsequent sub-clinical infection. Vaccine 26, 3469-3479

• Bronsvoort B.M.deC., Parida S., Handel I, McFarland S., Fleming L., Hamblin P., and Kock R.(2008) Serological survey for foot-and-mouth disease in wildlife in East Africa and parameter estimate of the Ceditest NSP ELISA for buffalo. Clin Vaccine Immunol. 2008 Jun;15(6):1003-11.

• Vannier P., Capua I., Le Potier M.F., Mackay D., Muylkens B., Parida S., Paton D.J., Thiry E. (2007). Marker vaccines and impact of their use on diagnostic and prophylactic measures (Review). Rev.Sci.tech.off.int.Epiz.,26(2)351-372..

• S Parida, L Fleming, Y Oh, M Mahapatra, Hamblin P, J Gloster, C Doel, S Gubbins and D J Paton (2007). Reduction of foot-and-mouth disease (FMD) virus load in nasal excretions, saliva and exhaled air of vaccinated pigs following direct contact challenge. Vaccine, 25 (45), 7806-7817.

• Parida S, Mahapatra m, Saikumar, Das Subash, Baron Michael, Anderson J and Barrett T (2007). Rescue of chimeric rinderpest virus with the nucleocapsid protein derived from Peste des Petits Ruminants virus: Use as a marker vaccine. Journal of General Virology, 88:7, 2019-2027.

• Perkins J, Parida S, Clavijo A. (2007). Use of a standardized bovine serum panel to evaluate a multiplexed nonstructural proteín antibody assay for serological surveillance of Foot-and-mouth disease. Clinical and Vaccine Immunology. Nov 07. 1472-1482.

• Satya Parida, Lucy Fleming, Debi Gibson, Pip A. Hamblin, Santina Grazioli, Emiliana Brocchi and David J. (2007). Bovine serum panel for evaluation of FMDV non structural protein antibody tests. In press". J. Vet. Diagn. Invest. 19(5),:539-544.

• Sarah Cox, Satya Parida, Charlotte Voyce, Scott Reid, Pip Hamblin, Geoff Hutchings, David J Paton, Paul Barnett (2007). Further evaluation of higher potency vaccines for early protection of cattle against FMDV direct contact challenge. Vaccine, 25 (44):7687-7695.

• D.J. Sammin, D. J. Paton, S. Parida, N. P. Ferris, G. H Gibson, M. Corteyn, N. J. Knowles, J. – F. Valarcher , P. A. Hamblin, L. Feming, G. Gwaze, K. J. Sumption. (2007). Evaluation of laboratory tests for SAT serotypes of foot-and-mouth disease virus withspecimens collected from convalescent cattle in Zimbabwe. Vet Record. 160: 647-654.

• Hema M, Nagendrakumar SB, Yamini R, Chandran D, Rajendra L, Thiagarajan D, Parida S, Paton DJ, Srinivasan VA, (2007) Chimeric tymovirus-like particles displaying foot-and-mouth disease virus non-structural protein epitopes and its use for detection of FMDV-NSP antibodies. Vaccine, 25(25): 4784-4794.

• Parida S, Anderson J, Cox S, Barnet PV and paton DJ. (2006). Secretory Ig A as an indicator of oropharyngeal FMDV replication. Vaccine 24:1107-1116.

• M. Mahapatra, S. Parida, M. D. Baron and T. Barrett. (2006). PPRV matrix (M) and glycoproteins (F/H) function better as a homologous complex: Development of a marker vaccine for PPRV. Journal of General Virology, 87(7): 2021-2029.

• Parida S, Cox S.J., Reid SM, Hamblin P, Barnet PV, Inoue T., Anderson J, Paton David. (2005). The application of new techniques to the improved detection of persistently infected cattle after vaccination and contact exposure to foot-and-mouth disease. Vaccine 23:5186-5195.

• Parida S, Mahapatra M., Hawes Pippa, Baron Michael, Monaghan Paul and Barrett Tom.(2005). Importance of the extracellular and cytoplasmic/transmembrane domains of the haemagglutinin protein of rinderpest virus for recovery of viable virus from cDNA copies. Virus Research 117:273-282.

• Parida S, OH Yooni, Reid Scott, Cox Sarah, Mahapatra Mana, Statham Bob, Barnet Paul, Anderson John, Charleston Bryan and Paton David.( 2006). Interferon-γ production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV. Vaccine 24:964-969.

• SJ Cox , Voyce C, Parida S, Reid S.M, Hamblin P. A, Paton D.J and Barnett P.V. (2006). Effect of antigen payload on protection, sub-clinical infection and persistence following direct contact challenge, Vaccine 24:3184-3190.

• Brocchi, E., I. E. Bergmann, A. Dekker, D. J. Paton, D. J. Sammin, M. Greiner, S. Grazioli, F. De Simone, H. Yadin, B. Haas, N. Bulut, V. Malirat, E. Neitzert, N. Goris, S. Parida, K. Sorensen, and K. De Clercq (2006). Comparative performance of six ELISAs for antibodies to the non-structural proteins of foot-and-mouth disease. Vaccine, 24:6966-6979.

• Paton DJ, Clercq KD, Greiner M, Dekker A, Brocchi E, Bergmann I, Sammin DJ, Gubbins S, Parida. (2006). Application of non-structural protein antibody tests in substantiating freedom from foot-and-mouth disease virus infection after emergency vaccination of cattle. Vaccine, 24:6503-6512.

• Toru Inoue, Satya Parida, David J Paton, Wilai Linchongsubongkoch, David Mackay, Yooni Oh, Dilok Aunpomma, Simon Gubbins, Takakiyo Saeki. (2006). Development and evaluation of an indirect ELISA to detect Foot-and-Mouth disease virus non-structural protein antibody using a chemically synthesized 2B peptide as antigen. Journal of Veterinary Dignostics and Investigation, 18:545-552.

• Kai Frolich, Chris Hamblin, Satya parida, Eeva Tuppurainen and Elvira Schettler.(2006). Serological survey on potential diseases agents of free ranging cervids in six selected National parks from Germany. Journal of wildlife Diseases, 42(4):836-843.

• Baron M.D., Banyard A., Parida S. and Barrett T. 2005. The Plowright vaccine strain of rinderpest virus has attenuating mutations in most genes. Journal of General Virology, 86:1093-1101.

• S. Reid, Parida S, King D P, Hutching G, Shaw A, Feris N, Zhang Z, Hilerton E,Paton DJ (2005). Use of automated real-time RT-PCR to detect foot and mouth disease virus in milk. Vterinary Research, 37 (10):121-132.

• Cox S.J, Voyce C, Parida S, Reid S.M, Hamblin P. A, Paton D.J and Barnett P.V.(2005) Protection against direct contact challenge following emergency FMD vaccination of cattle and the effect on virus excretion from the oropharynx. Vaccine, 23: 1106-1113

• Mahapatra M, Parida S, Egziabher BG, Diallo A, Barrett T. (2003). Sequence analysis of the phosphoprotein gene of Peste des petits ruminants (PPR) Virus: Editing of the Gene Transcript. Virus Research, 96(1-2): 85-98

• Forsyth MA, Parida S, Alexandersen S, Belsham GJ, Barrett T. (2003). Rinderpest virus lineage differentiation using RT-PCR and SNAP-ELISA. J Virol Methods. 107(1):29-36.

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