Dr. Sathya Velmurugan MVSc, PhD.
Dr. Sathya Velmurugan obtained her B. V. Sc. from Madras
Veterinary College, TANUVAS, Chennai. For M. V. Sc., she specialized in Animal
Reproduction, Gynaecology and Obstetrics at the College of Veterinary Science,
Punjab Agricultural University (now GADVASU), Ludhiana. She obtained her Ph. D.
in Biomedical Sciences (Neuroendocrinology) from the University of Edinburgh,
UK, where she studied actions of appetite peptides (leptin, secretin and NPY) on
hypothalamic oxytocin and vasopressin neurons in rats using in vivo
electrophysiology. She did her postdoctoral research at Rush University Medical
Center, Chicago (2009-11) and Rosalind Franklin University of Medicine and
Science, North Chicago (2011-13) in the field of Physiology. She joined the
National Institute of Animal Biotechnology in August 2013.
Infertility disorders, such as repeat breeding and anoestrus, remain as a major
problem in cattle and buffaloes even in organized farms. These disorders warrant
understanding reproductive physiology at the molecular, cellular and systemic
level so as to design novel therapeutic strategies. She is interested in the
regulation of reproductive axis and ovarian activity by the newly discovered
hypothalamic neuropeptide, kisspeptin. Kisspeptin research in cattle and
buffaloes has immense potential in treatment strategies for advancing puberty,
oestrus induction in anoestrous animals and improving conception in repeat
breeders. Male fertility constitutes half of the success rate in conception.
Hence, it is imperative to ensure that the semen quality is at its best in an
artificial insemination regimen. The ultimate test for semen quality is
fertility itself. However, in vitro semen function tests are also handy in
estimating the quality, especially when robust tests are used with advanced
technologies such as confocal microscopy and flow cytometry. In addition,
mitochondrial bioenergetics and respiratory chain activities also determine the
quality of spermatozoa. She is interested in studying these functions and
correlating them with fertility. To delve into basic research, she would like to
establish an electrophysiology lab to study the hypothalamic neurons involved in
reproduction in vivo as well as in brain slices.
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Velmurugan S, Russell JA and Leng G (2013) Systemic leptin increases the
electrical activity of supraoptic nucleus oxytocin neurones in virgin and late
pregnant rats. Journal of Neuroendocrinology 25 (4): 383-90.
Brunton PJ, Leng G and Russell JA (2010) Circulating secretin activates
supraoptic nucleus oxytocin and vasopressin neurons via noradrenergic pathways
in the rat. Endocrinology 151 (6): 2681-88.
Brunton PJ, Arunachalam S and
Russell JA (2009) Control of neurohypophysial hormone secretion, blood
osmolality and volume in pregnancy. Journal of Physiology and Pharmacology, 59
(Suppl 8): 29-45.
Tobin VA, Bull PM, Arunachalam S, O’Carroll AM, Ueta Y and
Ludwig M (2008) The effects of apelin on the electrical activity of hypothalamic
magnocellular vasopressin and oxytocin neurons and somatodendritic peptide
release. Endocrinology 49 (12): 6136-45.
Arunachalam S, Prabhakar S, Sangha
SPS and Ghuman SPS (2007) Vitamin E and selenium supplementation reduces plasma
cortisol and oxidative stress in dystocia affected buffaloes. Veterinary
Research Communications 31(7):809-18.
Arunachalam S and Prabhakar S (2006)
Haematological changes in dystociac buffaloes following dexamethasone
administration vis-à-vis normal parturition. Indian Journal of Animal Sciences
Arunachalam S, Prabhakar S, Ghuman SPS (2005) Effect of
dexamethasone administration on cortisol concentration and biochemical profile
in buffaloes suffering from dystocia. Animal Reproduction 2(4): 233-39.
Last updated date: January 08, 2014