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Dr. Sathya Velmurugan MVSc, PhD.
Scientist C
Email: sathya.velmurugan[at]niab[dot]org[dot]in

Dr. Sathya Velmurugan obtained her B. V. Sc. from Madras Veterinary College, TANUVAS, Chennai. For M. V. Sc., she specialized in Animal Reproduction, Gynaecology and Obstetrics at the College of Veterinary Science, Punjab Agricultural University (now GADVASU), Ludhiana. She obtained her Ph. D. in Biomedical Sciences (Neuroendocrinology) from the University of Edinburgh, UK, where she studied actions of appetite peptides (leptin, secretin and NPY) on hypothalamic oxytocin and vasopressin neurons in rats using in vivo electrophysiology. She did her postdoctoral research at Rush University Medical Center, Chicago (2009-11) and Rosalind Franklin University of Medicine and Science, North Chicago (2011-13) in the field of Physiology. She joined the National Institute of Animal Biotechnology in August 2013.

  Sathya Velmurugan
Research Interests:

Infertility disorders, such as repeat breeding and anoestrus, remain as a major problem in cattle and buffaloes even in organized farms. These disorders warrant understanding reproductive physiology at the molecular, cellular and systemic level so as to design novel therapeutic strategies. She is interested in the regulation of reproductive axis and ovarian activity by the newly discovered hypothalamic neuropeptide, kisspeptin. Kisspeptin research in cattle and buffaloes has immense potential in treatment strategies for advancing puberty, oestrus induction in anoestrous animals and improving conception in repeat breeders. Male fertility constitutes half of the success rate in conception. Hence, it is imperative to ensure that the semen quality is at its best in an artificial insemination regimen. The ultimate test for semen quality is fertility itself. However, in vitro semen function tests are also handy in estimating the quality, especially when robust tests are used with advanced technologies such as confocal microscopy and flow cytometry. In addition, mitochondrial bioenergetics and respiratory chain activities also determine the quality of spermatozoa. She is interested in studying these functions and correlating them with fertility. To delve into basic research, she would like to establish an electrophysiology lab to study the hypothalamic neurons involved in reproduction in vivo as well as in brain slices.


Selected Publications:
  • Velmurugan S, Russell JA and Leng G (2013) Systemic leptin increases the electrical activity of supraoptic nucleus oxytocin neurones in virgin and late pregnant rats. Journal of Neuroendocrinology 25 (4): 383-90.

  • Velmurugan S, Brunton PJ, Leng G and Russell JA (2010) Circulating secretin activates supraoptic nucleus oxytocin and vasopressin neurons via noradrenergic pathways in the rat. Endocrinology 151 (6): 2681-88.

  • Brunton PJ, Arunachalam S and Russell JA (2009) Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy. Journal of Physiology and Pharmacology, 59 (Suppl 8): 29-45.

  • Tobin VA, Bull PM, Arunachalam S, O’Carroll AM, Ueta Y and Ludwig M (2008) The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somatodendritic peptide release. Endocrinology 49 (12): 6136-45.

  • Arunachalam S, Prabhakar S, Sangha SPS and Ghuman SPS (2007) Vitamin E and selenium supplementation reduces plasma cortisol and oxidative stress in dystocia affected buffaloes. Veterinary Research Communications 31(7):809-18.

  • Arunachalam S and Prabhakar S (2006) Haematological changes in dystociac buffaloes following dexamethasone administration vis-à-vis normal parturition. Indian Journal of Animal Sciences 77(4): 300-33.

  • Arunachalam S, Prabhakar S, Ghuman SPS (2005) Effect of dexamethasone administration on cortisol concentration and biochemical profile in buffaloes suffering from dystocia. Animal Reproduction 2(4): 233-39.

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Last updated date: January 08, 2014
 
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