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Goel Name:


Designation:


Areas of Specialization:



E-mail:
Sandeep Goel


Scientist-F


Stem cell biology, reproductive biology, spermatogenesis, transgenesis, genome editing, conservation biology, animal biotechnology


goel[at]niab[dot]org[dot]in
     
Education and training:

Dr. Sandeep Goel completed his B.V. Sc. & A.H. (1996) with honours from Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, India, and M.V.Sc. (2000; Animal Biotechnology) from Tamil Nadu Veterinary and Animal Sciences University, Chennai, India. In 2000, he joined CSIR-Centre for Cellular and Molecular Biology (CCMB) as a scientist in the Genome Research Group where he worked at the National Facility for Transgenics and Gene Knockout Mice. In 2005, he was awarded the Japanese Government Fellowship (MEXT) to pursue a Ph.D. in Applied Bioscience from Kyoto University, Japan. After completion of his Ph.D. in 2008, he established his research group at the Laboratory for the Conservation of Endangered Species (LaCONES, an annex of CCMB) working towards the preservation of the reproductive potential of endangered males. Dr. Goel was a visiting faculty at Georgetown Medical School, Washington DC (October 2012-April 2013) and Associate Professor (tenure-track; March 2017-March 2019) at Kyoto University, Japan. Dr. Goel joined NIAB on 06 August 2020.


Research experience and interests:

Dr. Goel’s broad research focus is on reproductive biotechnology with specific emphasis on stem cell biology, animal transgenesis, testis biology, spermatogenesis, and cryobiology.

Dr. Goel’s research journey began with assessing the effect of growth factors and hormones on the development of in vitro-produced sheep embryos. Thereafter, he was involved in understanding functional genomics by the generation of transgenic (gene overexpression) and gene knockout (gene deletion) mice models. Using these models, Dr. Goel deciphered several molecular mechanisms and signaling pathways. One of the most interesting was the targeted deletion of the kappa-casein gene which caused the failure in lactation. This was the first-ever gene-targeted mice produced in the country using the ES cell technology. Thereafter, he moved onto pursue his research on male germline stem cells as an alternative to ES cells for the introduction of genetic modification in livestock species such as pigs and domestic buffaloes. In recent years, his research is focused on testis and germline stem cell cryopreservation, their revival, in vitro, and in vivo differentiation of germ cells, for the preservation of the genetic potential of domestic and wild animals. His most recent study deciphered the role of a testis-specific kinase, PBK/TOPK in spermatogenesis using the CRISPR-Cas9 gene knockout mice model.

Currently, Dr. Goel aims to develop mesenchymal stem cell cryo-banking for allogeneic and autologous transplantation that can aid in the broad-spectrum clinical application in livestock and companion animals.


Selected awards, honours and fellowships:
  1. Recipient of University Gold Medal (B.V.Sc. &A.H).
  2. Department of Biotechnology (DBT), fellowship for pursuing M.V.Sc. program in Animal Biotechnology.
  3. Japanese Government Monbukagakusho (MEXT) scholarship, 2005 for the Ph.D. studies at Kyoto University, Kyoto, Japan.
  4. Recipient of Indo-US Science and Technology Forum award (2012-13).
  5. Recipient of travel awards from Asia-Pacific Developmental Biology Network (APDBN), International Society for Stem Cell Research (ISSCR) and International Congress on Animal Reproduction (ICAR).
  6. Editorial board member of Scientific Reports, an online, open-access journal from the publishers of Nature.
  7. Reviewer for several journals.
  8. Life member of ISSCR, Association of the Promotion of DNA Finger Printing and other DNA Technologies (ADNAT), Indian Society for Study on Reproduction and Fertility (ISSRF) and Indian Society for Veterinary Immunology and Biotechnology (ISVIB).

Selected publications:

  1. Miki Y, Devi L, Imai Y, Koide T, Minami N and Goel S (2020). Male fertility is not impacted by the deletion of the PDZ-binding kinase (Pbk) gene in mice. Reproduction Fertility and Development 32 (10):893-902.
  2. Goel S and Minami N (2019). Altered hormonal milieu and dysregulated protein expression can cause spermatogenic arrest in ectopic xenografted immature rat testis. Scientific Reports 9 (1), 4036.
  3. Devi L, Pothana L and Goel S (2017). Dysregulation of angiogenesis-specific signaling in adult testis results in xenograft degeneration. Scientific Reports 7 (1), 2605.
  4. Varma VP, Devi L, Venna NK, Murthy CLN, Idris MM and Goel S (2015). Ocular fluid as a replacement for serum in cell cryopreservation media. PloS one 10 (7), e131291
  5. Makala H, Pothana L, Sonam S, Malla and Goel S (2015). Regeneration of Leydig cells in ectopically autografted adult mouse testes. Reproduction 49 (3), 259-268.
  6. Mahla R, Reddy N and Goel S (2012). Spermatogonial stem cells (SSCs) in buffalo (Bubalus bubalis) testis. PLoS One 7 (4), e36020.
  7. Reddy N, Mahla RS, Thati R, Suman SK, Jose J and Goel S (2012). Gonadal status of male recipient mice influences the germ cell development in immature buffalo testis tissue xenograft. Reproduction 135 (6), 785-796.
  8. Goel S, Reddy N, Mahla RS, Suman SK, and Pawar RM (2011). Spermatogonial stem cells in the testis of an endangered bovid: Indian blackbuck (Antilope cervicapra L.). Animal Reproduction Science 126: 251-257.
  9. Goel S, Sugimoto M, Minami N, Yamada M, Kume S, Imai H (2007). Identification, isolation, and in vitro culture of porcine gonocytes. Biology of Reproduction 77 (1), 127-137.
  10. Shekar P C*, Goel S*, Rani S D, Sarathi D P, Alex J L, Singh S, Kumar S (2006). kappa-casein-deficient mice fail to lactate. Proceeding of the National Academy of Science of the USA. 103 (21), 8000-8005 (*Equally contributing first authors)

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